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VIBRATION RESPONSE IMAGING (VRI) FOR PREDICTING POSTOPERATIVE LUNG FUNCTION IN PATIENTS WITH LUNG CANCER

The University of Texas MD Anderson Cancer Center, Houston, TX

PURPOSE: Preoperative radionuclide studies of regional ventilation and perfusion (<SUP>133</SUP>Xe-V/Q) together with lung function tests are established methods for predicting pulmonary function after resection for lung cancer. VRI technology records lung sounds, generating quantitative lung data indicative of the regional acoustic energy contributed by each lung. We compared the use of VRI with <SUP>133</SUP>Xe-V/Q for predicting postoperative lung function.

METHODS: Twenty-two patients (10F,age=65yrs<U>+</U>8yrs) with lung cancer referred for preoperative evaluation were enrolled. Recording by VRI-XP device (DeepBreeze, Or-Akiva, Israel) were done immediately after radiospirometric tests. Predicted postoperative FEV<SUB>1</SUB>(FEV<SUB>1</SUB>ppo) and DLco (DLco-ppo) were calculated by subtracting the percent functional uptake or percent acoustic energy of the lung to be resected from the total. VRI and <SUP>133</SUP>Xe-V/Q perfusion results were compared by Pearson correlation, absolute error (AE), and Wilcoxon test for paired data.

RESULTS: There was a good correlation between the VRI and <SUP>133</SUP>Xe-V/Q for the calculation of FEV<SUB>1</SUB>ppo (R=0.74) and DLco-ppo (R=0.79) There was no significant difference (p> 0.05) between the mean values of FEV<SUB>1</SUB>ppo as calculated by VRI (37%±12%) and <SUP>133</SUP>Xe-V/Q(39%±9%); AE=6.9±4.3. Similarly, there was no significant difference (p> 0.05) between the mean values of DLco-ppo as calculated by the VRI (37%±12%) and <SUP>133</SUP>Xe-V/Q (38%±14%); AE=6.7±5.1.

CONCLUSION: Prediction of postoperative lung function by VRI technology is similar to <SUP>133</SUP>Xe-V/Q . The present study is still ongoing and more data will be collected for continuation and confirmation of the present analysis.

CLINICAL IMPLICATIONS: VRI technology may play an important role in prediction of post-operative lung function. Furthermore, the VRI technology is non-invasive and radiation free, thus posing no risk to patients.

DISCLOSURE: Rodolfo Morice, Grant monies (from industry related sources) Department received grant monies for study from DeepBreeze, LTD; Product/procedure/technique that is considered research and is NOT yet approved for any purpose. VRI technique is considered research and is NOT yet approved for any purpose.